The Best and Safest Places to Stay in San Francisco: Top Luxury Hotels and Neighborhoods

When planning a visit to San Francisco, choosing the right accommodation is crucial, especially for travelers who prioritize luxury, quality, and yes—safety. Despite recent media coverage, San Francisco remains a safe and welcoming destination, particularly in its prime neighborhoods. In this guide, we’ll explore the best and safest places to stay in San Francisco, highlighting luxury hotels that cater to our most discerning travelers seeking an exceptional experience.

For those staying at any of these fine establishments, consider enhancing your visit with a private sightseeing tour with Spark Experiences in one of our luxury Tesla vehicles. Our friendly, professional guides will ensure that you see the best of San Francisco, from iconic landmarks to hidden gems, in safety, style and comfort.  Enjoy the peace of mind that comes from traveling with an experienced guide and a 5-star rated company.  By the end of your day exploring with us, you’ll fall in love with the City by the Bay!

Fairmont San Francisco: Historic Charm in One of the Best Neighborhoods to Stay

Located in the prestigious Nob Hill neighborhood, the original Fairmont San Francisco is a top choice for those looking for the best places to stay in San Francisco. This historic hotel, with its grand architecture and gracious amenities, offers a unique blend of old-world charm and character. Nob Hill is not only one of the safest and most exclusive neighborhoods in San Francisco, but also offers breathtaking views and easy access to popular attractions like Union Square and cable car rides.

As one of our favorite properties, the original Fairmont Hotel is often a featured destination in our classic San Francisco private tours.

(Tour pickup location: Tony Bennet Street main lobby)

Four Seasons Hotel San Francisco at Embarcadero: Modern Luxury in a Central Location

For travelers seeking modern elegance, the Four Seasons Hotel San Francisco Embarcadero stands out as one of the best luxury business-class hotels in San Francisco. Situated in the Financial District, this hotel offers stunning panoramic views of the city and the bay. The Financial District is an easy flat walk to the Embarcadero, Little Italy, Chinatown, Downtown, and the California St. Cable Car line, making it an ideal base for exploring.

(Tour pickup location: Sansome Street Valet entrance)

1Hotel San Francisco: Eco-Friendly Luxury in a Prime Embarcadero Location

1Hotel San Francisco, located near the Embarcadero, is a top choice for eco-conscious travelers who enjoy modern elegance in a waterfront location. This hotel offers a serene escape in one of the best neighborhoods to stay in San Francisco. With its emphasis on natural materials, sustainability, and signature “vibe”, 1Hotel provides a tranquil environment while being close to popular attractions.  Located right on the Embarcadero Waterfront Promenade and across street from the Ferry Building Marketplace, enjoy a morning jog or simply saunter out for craft coffee at the cities favorite gourmet food hall. The Embarcadero’s reputation as a safe and lively area, a favorite of locals and visitors alike, makes it an excellent choice for our guests.

(Tour pickup location: Mission Street)

Fairmont Heritage Place, Ghirardelli Square: Family-Friendly Suites in a Safe and Iconic Area

For families planning an extended stay, the Fairmont Heritage Place at Ghirardelli Square offers luxurious residential-style suites in one of San Francisco’s most touristic and family-friendly neighborhoods. With its close proximity to Fisherman’s Wharf, Pier 39, the Hyde Street Cable Car and other attractions geared for all ages, this hotel is among the best places to stay in San Francisco for those traveling with children. The spacious suites, complete with full kitchens, provide all the comforts of home with a historic and maritime vibe.

Due to its location to the Northwest of downtown and proximity to the Golden Gate Bridge/ Hwy 101, this is an ideal departure point for those wishing to embark on a Muir Woods private tour to see the Coastal Redwoods, or Napa Wine Country.

(Tour pickup location: North Point at Polk St.)

St. Regis San Francisco: Sophistication Near the Moscone Center in SoMa

If you’re attending an event at the Moscone Convention Center, the St. Regis San Francisco offers unparalleled proximity and sophistication. Located in the SoMa district, this hotel is a top pick for those looking for the best places to stay in San Francisco near numerous cultural landmarks and museums like the SFMOMA. The Yerba Buena Gardens district of SoMa is a vibrant urban neighborhood, providing both convenience and a wealth of dining and entertainment options.

Because of its proximity to both the Bay Bridge and southbound highway, this is an ideal departure point for our Silicon Valley private tours.

(Tour pickup location: Minna St Valet)

Conclusion: Your Guide to the Best and Safest Places to Stay in San Francisco

San Francisco continues to be a vibrant and safe destination, especially when you choose to stay in one of the city’s top luxury hotels located in its best neighborhoods. Whether you’re drawn to the historic charm of Nob Hill, the modern luxury of the Embarcadero, or the family-friendly amenities near Ghirardelli Square, San Francisco offers a variety of accommodations that cater to the needs of affluent and safety-conscious travelers.

By choosing from these carefully selected hotels, and perhaps adding a personalized tour with Spark Experiences, you can enjoy the best of what San Francisco has to offer—worry-free unforgettable experiences in one of the world’s most beautiful cities.